CytoSMART™ is becoming more and more known in the field of life science, cell culturing in particular. Moreover, CytoSMART™ Lux (2) is used in revolutionary research which has led to the creation of multiple articles. In this blog we would like to present some examples of the broad application of our in-incubator imaging device to you!
Parker, F., White, K., Phillips, S. et al. used our CytoSMART™ Lux in their research and wrote the article: Promoting differentiation of cultured myoblasts using biomimetic surfaces that present alpha-laminin-2 peptides. Cytotechnology (2016) 68: 2159. doi: 10.1007/s10616-016-0006-y. More specifically, they describe the usage of our CytoSMART™ Lux cell-coverage-tracking-function. Since this research required monitoring cells but also minimising any disturbance to the cells, it was an obvious choice to use our CytoSMART™ Lux (2)! You can read the full publication here.
The ATG16L1 risk allele associated with Crohn’s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines. Mucosal Immunology, (2016) doi:10.1038/mi.2016.65 written by Wildenberg, M.E. et al. used our CytoSMART™ Lux to monitor cells. Like the title of the article already implies, Wildenberg, M.E et al. investigated Crohn’s disease. They found an association between the effectiveness of thiopurines (drug used for treating Crohn’s disease patients) and ATG16L1 risk allele which is an allele found in 30% of patients with Crohn’s disease. Read the full publication >
Jlenia Brunetti, et al. used our CytoSMART™ Lux in the research described in: Insights into the role of sulfated glycans in cancer cell adhesion and migration through use of branched peptide probe. Sci. Rep. 6, 27174 (2016) doi: 10.1038/srep27174. The images made on a pre-set time-interval easily follow the adhesion and migration of cancer cells. Read the full publication >
Additionally, our in-incubator imaging system CytoSMART Lux2 was used in the tissue-engineering research of Homan, K. A. et al. Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips. Sci. Rep. 6, 34845; doi: 10.1038/srep34845 (2016). They describe a very promising “bioprinting method which opens new avenues for creating 3D organs-on-a-chip that better recapitulate in vivo microenvironments, which could enable advances in drug screening, mechanistic drug studies, disease models, and ultimately, regenerative medicine.” The full publication is presented here >
We at CytoSMART™ are very proud to be part of such promising research and are already looking forward to the next articles!