Abietane diterpenes from Abies spectabilis and their anti-pancreatic cancer activity against the MIA PaCa-2 cell line

Authors: Phan ND, Omar AM, Sun S, Maneenet J, Dibwe DF, Sato M, Kalauni SK, Toyooka N, Fujii T, Awale S.

Bioorganic & Medicinal Chemistry Letters, Volume 66, 2022


In this study, a phytochemical investigation of Abies spectabilis extract was carried out, leading to the isolation of ten compounds possessing anti-cancer properties. The CytoSMART live-cell imaging system was used to examine the effect of one of these compounds (dehydroabietinol) on MIA PaCa-2 human pancreatic cancer cell migration. The results suggested that dehydroabietinol suppresses the migration of MIA PaCa-2 cells.