Design and synthesis of novel pipernonaline derivatives as anti-austerity agents against human pancreatic cancer PANC-1 cells

Author: Okada, T., Chino, Y., Yokoyama, K., Fujihashi, Y., Phan, N.D., Maneenet, J., Prudhvi, L., Awale, S. and Toyooka, N.

Bioorganic & Medicinal Chemistry, 2022


This study investigated the effects of pipernonaline derivatives with potential anti-austerity properties as novel agents against pancreatic cancer. The CytoSMART Lux2 was used to analyze the migration patterns of human pancreatic cancer PANC-1 cells using quantitative real-time cell migration assay. It was found that one of the derived compounds, termed Compound 9, showed the strongest preferential cytotoxicity against PANC-1 cells by inhibiting Akt activation and cancer cell migration, making it a highly promising candidate for anti-pancreatic cancer treatments.