Author: Vadovics, M., Ho, J., Igaz, N., Alföldi, R., Rakk, D., Veres, É., Szücs, B., Horváth, M., Tóth, R., Szücs, A. and Csibi, A.
American Society for Microbiology, 2022
The authors of this study investigated the potential of Candida albicans to affect oral squamous cell carcinoma (OSCC) tumor development and progression. The CytoSMART Lux2 was used to assess migration of OSCC cell lines treated with C. albicans or C. parapsilosis in a standard wound healing assay. Overall, it was found that increased fungal burden and, specifically, infection with live C. albicans resulted in upregulation of oncogenes and development of premalignant phenotype, indicating C. albicans involvement in early and late stages of malignant promotion and progression of oral cancer.
