Induction of 2-hydroxycatecholestrogens O-methylation: A missing puzzle piece in diagnostics and treatment of lung cancer

Author: Musial C, Knap N, Zaucha R, Bastian P, Barone G, Lo Bosco G, Lo-Celso F, Konieczna L, Belka M, Bączek T, Gammazza A M, Kuban-Jankowskaa A, Cappello F, Nussberger S, Gorska-Ponikowska M.

Redox Biology, 2022

The authors of this study examined the influence of 2-methoxyestradiol (2-ME), a major metabolite of 17ß-estradiol (E2), on non-small cell lung cancer (NSCLC) cells as a potential therapy for patients suffering from NSCLC. The CytoSMART Omni was used for a cellular confluency analysis to determine the optimal cell density for A549 cells, a human lung epithelial carcinoma cell line. Moreover, the CytoSMART Lux3 FL was used to assess the viability of the 2-ME-treated A549 cells. All in all, the results show that 2-ME induced cell death in the lung cancer cellular model, suggesting that 2-ME can be used as a possible therapeutic adjuvant.